Abstract: Toxicity experiments, mutation experiments and 30-day feeding tests were conducted on rats with transgenic rice bearing mtlD/gutD gene. Results showed that oral LD 50 for rats was larger than 30 g/kg and no mutations were found. The rats groups with 18,36,54 g/kg-dosage had good development in 30-day feeding test. No obvious differences were found in the index of weight, food utilization rate, routine blood test, rate of organ to body (weight to weight), and patho-histological observations between the rats fed with or without the transgenic rice grain. It could be concluded that transgenic rice with mtlD/gutD gene was safe to the rats.

Key words: transgenic rice, rice grain, toxicity experiment, mutation experiment, feeding test

摘要： 对转mtlD/gutD双价基因稻米进行了大鼠急性、亚急性毒性实验，致突变试验和30 d喂养试验。结果表明,大鼠经口LD50＞30 g/kg体质量，无致突变作用；30 d喂养试验中，18、36、54 g/kg体质量各剂量组大鼠发育、增重、食物利用率、血常规、脏体比及病理组织学观察等各项指标与基础对照组相比均无显著差异。初步表明转mtlD/gutD双价基因稻米对大鼠来说是安全的。

关键词: 转基因, 稻米, 毒性试验, 致突变试验