二化螟对双酰胺类杀虫剂的抗药性监测和交互抗性研究

doi:10.16819/j.1001-7216.2017.6124 307

摘要/Abstract

摘要：

【目的】为了及时了解我国主要稻区二化螟对氯虫苯甲酰胺和氟苯虫酰胺的抗药性发展情况,同时明确对氯虫苯甲酰胺原药和制剂的抗性水平是否存在差异及二化螟对新研发的双酰胺类杀虫剂溴氰虫酰胺、四氯虫酰胺及氯氟氰虫酰胺与氯虫苯甲酰胺、氟苯虫酰胺间是否存在交互抗性。【方法】采用稻苗浸渍法测定了2015年我国7省19地二化螟田间种群对氯虫苯甲酰胺和氟苯虫酰胺的抗药性,同时测定了浙江余姚和象山两个抗性种群对97.3%氯虫苯甲酰胺原药、20%氯虫苯甲酰胺悬浮剂制剂的抗药性及其对溴氰虫酰胺、四氯虫酰胺及氯氟氰虫酰胺与氯虫苯甲酰胺和氟苯虫酰胺间的交互抗性。【结果】浙江余姚和苍南种群对氯虫苯甲酰胺已达141.1倍和135.0倍的高水平抗性,象山种群为87.9倍的中等水平抗性;这三个种群对氟苯虫酰胺均表现为中等水平抗性(15.0~58.7倍)。二化螟对97.3%氯虫苯甲酰胺原药和20%氯虫苯甲酰胺悬浮剂制剂存在抗性差异,浙江余姚和象山种群对制剂的抗性更高。交互抗性研究结果显示,对氟苯虫酰胺和氯虫苯甲酰胺均产生了中到高水平抗性(27.6~133.6倍)的象山、余姚种群,对溴氰虫酰胺、四氯虫酰胺和氯氟氰虫酰胺同样也产生了中到高水平抗性(30.3~127.0倍)。【结论】各二化螟地理种群之间对氯虫苯甲酰胺和氟苯虫酰胺抗药性差异较大,分别表现出117.6倍和146.8倍的差异,浙江余姚和象山二化螟种群对20%氯虫苯甲酰胺悬浮剂制剂抗药性更高且三种新双酰胺类杀虫剂与氯虫苯甲酰胺和氟苯虫酰胺之间存在交互抗性。

关键词: 二化螟, 双酰胺药剂, 抗药性, 交互抗性

Abstract:

【Objective】 We aim to learn about the chlorantraniliprole and flubendiamide resistance development of Chilo suppressalis from the main rice-growing area in China, meanwhile, to define the difference between resistance levels to 97.3% chlorantraniliprole TC and 20% chlorantraniliprole SC and the cross-resistance between cyantraniliprole, tetrachlorantraniliprole, cyhalodiamide and chlorantraniliprole, flubendiamide in Yuyao and Xiangshan resistance populations.【Method】 The resistance levels of nineteen Chilo suppressalis populations collected from seven provinces to chlorantraniliprole and flubendiamide, the resistance levels to 97.3% chlorantraniliprole TC and 20% chlorantraniliprole SC and the cross-resistance between cyantraniliprole, tetrachlorantraniliprole, cyhalodiamide and chlorantraniliprole, flubendiamide in Yuyao and Xiangshan resistance populations, were monitored by rice seeding dipping method in 2015. 【Result】 Yuyao and Cangnan populations from Zhejiang Province have developed high level of resistance to chlorantraniliprole (141.1-fold and 135.0-fold), and Xiangshan population also showed moderate level of resistance (87.9-fold). Moreover, the three field populations showed moderate level of resistance to flubendiamide (15.0-fold to 58.7-fold). In addition, Yuyao and Xiangshan populations showed various resistance ratios to 97.3% chlorantraniliprole TC and 20% chlorantraniliprole SC in with higher resistance ratio to 20% chlorantraniliprole SC. The result showed the two populations both have reached moderate or high level of resistance to flubendiamide and chlorantraniliprole (27.6-fold to 133.6-fold), meanwhile they also have exhibited moderate or high level of resistance to cyantraniliprole, SPY-9080 and cyantraniliprole (30.3-fold to 120.7-fold).【Conclusion】 Significant variations among field populations to chlorantraniliprole and flubendiamide were observed, showing 117.6-fold and 146.8-fold differences, respectively, as well as the higher resistance ratio to 20% chlorantraniliprole SC in Yuyao and Xiangshan resistance populations and strong cross-resistance among cyantraniliprole, tetrachlorantraniliprole, cyhalodiamide and chlorantraniliprole, flubendiamide.

Key words: Chilo suppressalis, diamides, insecticide resistance, cross-resistance

中图分类号:

赵丹丹, 周丽琪, 张帅, 姚蓉, 邱运霞, 高聪芬. 二化螟对双酰胺类杀虫剂的抗药性监测和交互抗性研究[J]. 中国水稻科学, 2017, 31(3): 307-314.

Dandan ZHAO, Liqi ZHOU, Shuai ZHANG, Rong YAO, Yunxia QIU, Congfen GAO. Resistance Monitoring and Cross-resistance to the Diamides in the Rice Stem Borer, Chilo suppressalis (Lepidoptera: Pyralidae)[J]. Chinese Journal OF Rice Science, 2017, 31(3): 307-314.

图/表 5

参考文献 30

[1]	丁锦华,苏建亚. 农业昆虫学. 北京:中国农业出版社,2001.
	Ding J H, Su J Y. Agricultural Entomology.Beijing: China Agricultural Press,2001. (in Chinese)
[2]	胡君,陈文明,张真真,郑雪松,靳建超,苏建亚,高聪芬,沈晋良. 长江流域稻区二化螟抗药性监测. 中国水稻科学,2010,24(5): 509-515.
	Hu J, Chen W M, Zhang Z Z, Zheng X S, Jin J C, Su J Y, Gao C F, Shen J L.Insecticide resistance monitoring of Chilo suppressalis in the drainage area of the Yangtze River, China. Chin J Rice Sci, 2010, 24(5): 509-515.(in Chinese with English abstract)
[3]	Ozaki K.Resistance to parathion in the rice stem borer, Chilo suppressalis Walker.Botyu Kagaku, 1962, 27: 81-96.
[4]	苏建坤,褚柏. 扬州地区水稻二化螟抗药性监测.南京农业大学学报, 1987,4(增刊): 56-63.
	Su J K, Chu B.Resistance monitoring of the rice stem borer, Chilo suppressalis Walker in Yangzhou region . J Nanjing Agric Univ, 1987, 4(Suppl): 56-63. (in Chinese)
[5]	蒋学辉,章强华,胡仕孟,谢士杰,徐喜刚. 浙江省水稻二化螟抗药性现状与治理对策. 植保技术与推广,2001,21(3):27-29.
	Jiang X H, Zhang Q H, Hu S M, Xie J S, Xu X G.The status of pesticide of rice stalk borer in Zhe Jiang Provice and their management tactics.Plant Prot Technol Ext, 2001, 21(3): 27-29. (in Chinese with English abstract)
[6]	曲明静,韩召军,许新军,邵晓玲,田学志,符明龙. 二化螟对三唑磷的抗性发生动态与风险评估. 南京农业大学学报, 2005, 28(3): 38-42.
	Qu M J, Han Z J, Xu X J, Shao X L, Tian X Z, Fu M L.Dynamics and risk assessment of triazophos resistance in rice stem borer (Chilo suppressalis Walker).J Nanjing Agric Univ, 2005, 28(3): 38-42. (in Chinese with English abstract)
[7]	熊件妹,朱杏芬,肖海军. 南昌地区二化螟抗药性监测与治理. 江西农业大学学报,2006,28(6):877-880.
	Xiong J M, Zhu X F, Xiao H J.Monitoring and administering of resistance of rice stem borer, Chilo suppressalis to 4 conventional insecticides in Nanchang region.Acta Agric Univ Jiangxiensis, 2006, 28(6): 877-880.(in Chinese with English abstract)
[8]	He Y P, Gao C F, Chen W M, et al.Comparison of dose responses and resistance ratios in four populations of the rice stem borer, Chilo suppressalis (Lepidoptera: Pyralidae), to 20 insecticides.Pest Manag Sci, 2008, 64: 308-315.
[9]	徐尚成,俞幼芬,王晓军,万琴. 新杀虫剂氯虫苯甲酰胺及其研究开发进展. 现代农药,2008,7(5): 8-11.
	Xu S C, Yu Y F, Wang X J, Wan Q.Rynaxypyr, a new insecticide and its research & development in application .Modern Agrochem, 2008, 7(5): 8-11. (in Chinese with English abstract)
[10]	Wu M, Zhang S, Yao R, Wu S, Su J, Gao C F.Susceptibility of the Rice Stem Borer, Chilo suppressalis (Lepidoptera: Crambidae), to Flubendiamide in China.J Ecol Entomol, 2014, 107(3): 1250-1255.
[11]	Gao C F, Yao R, Zhang Z Z, Zhang S, Su J Y.Susceptibility baseline and chlorantraniliprole resistance monitoring in Chilo suppressalis (Lepidoptera: Pyralidae). J Ecol Entomol, 2013, 106(5): 2190-2194.
[12]	Su J Y, Zhang Z Z, Wu M, Gao C F.Geographic susceptibility of Chilo suppressalis Walker (Lepidoptera: Crambidae ) , to chlorantraniliprole in China.Pest Manag Sci, 2014, 70(6): 989-995.
[13]	Foster S P, Denholm L, Rison J L, Portillo H E, Margaritopoulis J, Slater R.Susceptibility of standard clones and European field populations of the green peach aphid, Myzus persicae, and the cotton aphid, Aphis gossypii (Hemiptera: Aphididae), to the novel anthranilic diamide insecticide cyantraniliprole.Pest Manag Sci, 2012, 68(4): 629-633.
[14]	李斌,杨辉斌,王军锋,宋玉泉. 四氯虫酰胺的合成及其杀虫活性. 现代农药,2014,13(3):17-21.
	Li B, Yang H B, Wang J F, Song Y Q.Synthesis and insecticidal activity of Si Lv Chong Xian'an.Modern Agrochem, 2014, 13(3): 17-21. (in Chinese with English abstract)
[15]	邢家华,朱冰春,袁静,郁季平,董德臻,周冬英,胡冬松,陈杰. 新型杀虫剂氯氟氰虫酰胺对不同鳞翅目害虫的毒力和田间防效与方法. 农药学学报,2013,15(2):159-164.
	Xing J H, Zhu B C, Yuan J, Yu J P, Dong D Z, Zhou D Y, Hu D S, Chen J.Bioactivity and field efficacy of novel insecticide ZJ4042 against different lepidopterous pests.Chin J Pest Sci, 2013, 15(2): 159-164. (in Chinese with English abstract)
[16]	董卫莉,徐俊英,刘幸海,赵卫光,李正名. 昆虫鱼尼汀受体及以其为靶标的杀虫剂的研究进展. 农药学学报,2008,10(2):178-185.
	Dong W L, Xu J Y, Liu X H, Zhao W G, Li Z M.Progress on insect ryanodine receptor and insecticides targeting at ryanodine receptor.Chin J Pest Sci, 2008, 10(2): 178-185.
[17]	杨桂秋,黄琦,陈霖,辉斌,于海波,李斌. 新型杀虫剂溴氰虫酰胺研究概述. 世界农药,2012,34(12): 19-21.
	Yang G Q, Huang Q, Chen L, Hui B, Yu H B, Li B.Research review on a novel insecticide cyantraniliprole.World Pesi, 2012, 34(12): 19-21. (in Chinese)
[18]	Liu X, Wang H Y, Ning Y B, Qiao K, Wang K Y.Resistance selection and characterization of chlorantraniliprole resistance in Plutella xylostella (Lepidoptera: Plutellidae).J Eco Entomol, 2015, 108(4): 1978-1985.
[19]	Wang X, Khakame S K, Ye C, Yang Y, Wu Y.Characterisation of field-evolved resistance to chlorantraniliprole in the diamondback moth, Plutella xylostella, from China. Pest Manag Sci, 2013, 69(5): 661-665.
[20]	Sang S, Shu B S, Yi X, Liu J, Hu M, Zhong G.Cross- resistance and baseline susceptibility of Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae) to cyantraniliprole in the south of China.Pest Manag Sci, 2015, 72(5): 922-928.
[21]	Campos M R, Silva T B, Silva W M, Silva J E, Siqueira H A.Susceptibility of Tuta absoluta (Lepidoptera: Gelechiidae) Brazilian populations to ryanodine receptor modulators.Pest Manag Sci, 2015, 71(4): 537-544.
[22]	Han L Z, Li S B, Liu P L, Peng Y F, Hu M L.New artificial diet for continuous rearing of Chilo suppressalis Walker (Lepidoptera: Crambidae).Arthrop Biol, 2012, 105(2): 253-258.
[23]	中华人民共和国农业部. NY/T 2058-2014.中华人民共和国农业行业标准,水稻二化螟抗药性监测技术规程.北京:中国农业出版社,2014.
	Ministry of agriculture of the People's Republic of China. NY/T 2058-2014. Agricultural industry standard of the People's Republic of China, Technological rules for monitoring insecticide resistance in striped stem borer, Chilo suppressalis Walker. Beijing: China Agriculture Press, 2014.
[24]	Wang X L, Li X Y, Shen A, Wu Y.Baseline susceptibility of the diamondback moth (Lepidoptera: Plutellidae) to chlorantraniliprole in China.J Ecol Entomol, 2010, 103(3): 843-848. (in Chinese)
[25]	胡珍娣,冯夏,李振宇,张德雍,陈焕瑜. 不同小菜蛾田间种群对氯虫苯甲酰胺药剂的敏感性. 农药研究与应用, 2010, 14(3): 25-27.
	Hu Z D, Feng X, Li ZY, Zhang D Y, Chen H Y.Studies on the susceptibility of diamondback moth (DBM) Plutella xylostella L. to chlorantraniliprole in different vegetable fields.Agrochem Res Appl, 2010, 14(3): 25-27. (in Chinese)
[26]	胡珍娣,陈焕瑜,李振宇,张德雍,尹飞,林庆胜,包华理,周小毛,冯夏. 华南小菜蛾田间种群对氯虫苯甲酰胺已产生严重抗性. 广东农业科学,2012(1):79-81.
	Hu Z D, Chen H Y, Li Z Y, Zhang D Y, Yin F, Lin Q S, Bao L H, Zhou X M, Feng X.Found a field population of diamondback moth, Plutella xylostella (L.), with high-level resistance to chlorantraniliprole in South China.Guangdong Agric Sci, 2012, (1): 79-81. (in Chinese)
[27]	Wang X L, Khakame S K, Ye C, Yang Y, Wu Y.Characterisation of field-evolved resistance to chlorantraniliprole in the diamondback moth, Plutella xylostella, from China.Pest Manag Sci, 2013, 69(5): 661-665.
[28]	Su J Y, Lai T C, Li J.Susceptibility of field populations of Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae) in China to chlorantraniliprole and the activities of detoxification enzymes. Crop Prot, 2012, 42: 217-222.
[29]	Lai T C, Li J, Su J Y.Monitoring of beet armyworm Spodoptera exigua ( Lepidoptera: Noctuidae) resistance to chlorantraniliprole in China.Pest Biol Physiol, 2011, 101(3): 198-205.
[30]	Li X C, Degain B A, Harpold V S, Marçon P G, Nichols RL, Fournier A J, Naranjo S E, Palumbo J C, Ellsworth P C.Baseline susceptibilities of B- and Q-biotype Bemisia tabaci to anthranilic diamides in Arizona.Pest Manag Sci, 2012, 68: 83-91.

采集地点 Collection site				测定代次 Generation
湖南东安 Dong’an, Hunan Province	DA	04-02	蛹 Pupa	F₁
湖南攸县 Youxian, Hunan Province	YX	04-30	卵块 Egg	F₀
湖南芷江 Zhijiang, Hunan Province	ZJ	05-22	卵块 Egg	F₀
浙江苍南 Cangnan, Zhejiang Province	CN	04-11	老熟幼虫 Mature larvae	F₁
浙江瑞安 Ruian, Zhejiang Province	RA	04-25	卵块 Egg	F₀
浙江象山 Xiangshan, Zhejiang Province	XS	06-30	蛹 Pupa	F₁
浙江余姚 Yuyao, Zhejiang Province	YY	05-21	卵块 Egg	F₀
湖北孝感 Xiaogan, Hubei Province	XG	05-14	卵块 Egg	F₀
湖北荆州 Jingzhou, Hubei Province	JZ	04-04	老熟幼虫 Mature larvae	F₁
湖北监利 Jianli, Hubei Province	JL	08-26	卵块 Egg	F₀
安徽潜山 Qianshan, Anhui Province	QS	05-08	卵块 Egg	F₀
安徽庐江 Lujiang, Anhui Province	LJ	08-15	幼虫 Larvae	F₁
安徽徽州 Huizhou, Anhui Province	HZ	05-17	卵块 Egg	F₀
江西上高 Shanggao, Jiangxi Province	SG	04-05	老熟幼虫 Mature larvae	F₁
江西南城 Nancheng, Jiangxi Province	NC	04-11	卵块 Egg	F₀
江苏仪征 Yizheng, Jiangsu Province	YZ	05-27	卵块 Egg	F₀
江苏邗江 Hanjiang, Jiangsu Province	HJ	05-28	卵块 Egg	F₀
四川乐山 Leshan, Sichuan Province	LS	07-24	蛹 Pupa	F₁
四川绵阳 Mianyang, Sichuan Province	MY	08-30	幼虫 Larvae	F₁

采集地点 Collection site				测定代次 Generation
湖南东安 Dong’an, Hunan Province	DA	04-02	蛹 Pupa	F₁
湖南攸县 Youxian, Hunan Province	YX	04-30	卵块 Egg	F₀
湖南芷江 Zhijiang, Hunan Province	ZJ	05-22	卵块 Egg	F₀
浙江苍南 Cangnan, Zhejiang Province	CN	04-11	老熟幼虫 Mature larvae	F₁
浙江瑞安 Ruian, Zhejiang Province	RA	04-25	卵块 Egg	F₀
浙江象山 Xiangshan, Zhejiang Province	XS	06-30	蛹 Pupa	F₁
浙江余姚 Yuyao, Zhejiang Province	YY	05-21	卵块 Egg	F₀
湖北孝感 Xiaogan, Hubei Province	XG	05-14	卵块 Egg	F₀
湖北荆州 Jingzhou, Hubei Province	JZ	04-04	老熟幼虫 Mature larvae	F₁
湖北监利 Jianli, Hubei Province	JL	08-26	卵块 Egg	F₀
安徽潜山 Qianshan, Anhui Province	QS	05-08	卵块 Egg	F₀
安徽庐江 Lujiang, Anhui Province	LJ	08-15	幼虫 Larvae	F₁
安徽徽州 Huizhou, Anhui Province	HZ	05-17	卵块 Egg	F₀
江西上高 Shanggao, Jiangxi Province	SG	04-05	老熟幼虫 Mature larvae	F₁
江西南城 Nancheng, Jiangxi Province	NC	04-11	卵块 Egg	F₀
江苏仪征 Yizheng, Jiangsu Province	YZ	05-27	卵块 Egg	F₀
江苏邗江 Hanjiang, Jiangsu Province	HJ	05-28	卵块 Egg	F₀
四川乐山 Leshan, Sichuan Province	LS	07-24	蛹 Pupa	F₁
四川绵阳 Mianyang, Sichuan Province	MY	08-30	幼虫 Larvae	F₁

省份 Province	种群 Strain/Population	斜率(标准误) Slope (SE)	卡方值(自由度) χ2 (df)	LC₅₀(95%置信限) LC₅₀(95% confidence interval)/(mg·L^-1)	抗性倍数 Resistance ratio
	SS(敏感Susceptible)	2.473(0.290)	2.260(4)	0.693(0.549–0.858)	1.0
湖南Hunan	DA	2.061(0.247)	1.862(3)	3.456(2.581–4.546)	5.0
	YX	1.295(0.167)	0.785(3)	4.622(3.216–6.647)	6.7
	ZJ	1.336(0.161)	2.569(4)	3.455(2.317–5.047)	5.0
浙江Zhejiang	RA	1.298(0.168)	1.566(3)	3.306(2.269–4.729)	4.8
	XS	0.836(0.118)	0.999(4)	60.903(37.531–110.653)	87.9
	YY	1.485(0.220)	2.232(4)	97.772(69.794–139.611)	141.1
	CN	1.382(0.261)	0.213(3)	93.583(61.714–138.667)	135.0
湖北Hubei	XG	1.058(0.177)	0.035(3)	2.787(1.432–4.661)	4.0
	JZ	1.251(0.216)	1.211(3)	4.610(2.483–7.438)	6.7
	JL	0.871(0.126)	0.496(4)	10.969(6.403–18.745)	15.8
安徽Anhui	QS	1.156(0.159)	0.074(3)	5.230(3.533–7.867)	7.5
	LJ	0.907(0.151)	0.142(3)	9.917(6.139–18.483)	14.3
	HZ	0.963(0.186)	0.368(3)	2.100(1.026–3.940)	3.0
江西Jiangxi	SG	1.543(0.184)	1.239(3)	4.651(3.391–6.408)	6.7
江西Jiangxi	NC	1.237(0.141)	2.327(4)	15.220(10.700–22.330)	22.0
江苏Jiangsu	YZ	0.791(0.150)	0.910(3)	1.169(0.590–2.109)	1.7
江苏Jiangsu	HJ	0.941(0.162)	0.430(3)	1.169(0.619–1.997)	1.7
四川Sichuan	LS	2.061(0.247)	1.862(3)	3.456(2.581–4.546)	5.0
四川Sichuan	MY	0.985(0.153)	0.612(3)	0.806(0.473–1.255)	1.2

省份 Province	种群 Strain/Population	斜率(标准误) Slope (SE)	卡方值(自由度) χ2 (df)	LC₅₀(95%置信限) LC₅₀(95% confidence interval)/(mg·L^-1)	抗性倍数 Resistance ratio
	SS(敏感Susceptible)	2.473(0.290)	2.260(4)	0.693(0.549–0.858)	1.0
湖南Hunan	DA	2.061(0.247)	1.862(3)	3.456(2.581–4.546)	5.0
	YX	1.295(0.167)	0.785(3)	4.622(3.216–6.647)	6.7
	ZJ	1.336(0.161)	2.569(4)	3.455(2.317–5.047)	5.0
浙江Zhejiang	RA	1.298(0.168)	1.566(3)	3.306(2.269–4.729)	4.8
	XS	0.836(0.118)	0.999(4)	60.903(37.531–110.653)	87.9
	YY	1.485(0.220)	2.232(4)	97.772(69.794–139.611)	141.1
	CN	1.382(0.261)	0.213(3)	93.583(61.714–138.667)	135.0
湖北Hubei	XG	1.058(0.177)	0.035(3)	2.787(1.432–4.661)	4.0
	JZ	1.251(0.216)	1.211(3)	4.610(2.483–7.438)	6.7
	JL	0.871(0.126)	0.496(4)	10.969(6.403–18.745)	15.8
安徽Anhui	QS	1.156(0.159)	0.074(3)	5.230(3.533–7.867)	7.5
	LJ	0.907(0.151)	0.142(3)	9.917(6.139–18.483)	14.3
	HZ	0.963(0.186)	0.368(3)	2.100(1.026–3.940)	3.0
江西Jiangxi	SG	1.543(0.184)	1.239(3)	4.651(3.391–6.408)	6.7
江西Jiangxi	NC	1.237(0.141)	2.327(4)	15.220(10.700–22.330)	22.0
江苏Jiangsu	YZ	0.791(0.150)	0.910(3)	1.169(0.590–2.109)	1.7
江苏Jiangsu	HJ	0.941(0.162)	0.430(3)	1.169(0.619–1.997)	1.7
四川Sichuan	LS	2.061(0.247)	1.862(3)	3.456(2.581–4.546)	5.0
四川Sichuan	MY	0.985(0.153)	0.612(3)	0.806(0.473–1.255)	1.2

省份 Province	种群 Strain/Population	斜率(标准误) Slope (SE)	卡方值(自由度) χ2 (df)	LC₅₀(95%置信限) LC₅₀(95% confidence interval)/(mg·L^-1)	抗性倍数 Resistance ratio
	SS(敏感Susceptible)	2.172(0.283)	1.949(4)	0.217(0.173–0.266)	1.0
湖南Hunan	DA	1.037(0.161)	0.728(3)	0.245(0.140–0.387)	1.1
	YX	0.990(0.151)	0.178(3)	0.397(0.249–0.623)	1.8
	ZJ	0.879(0.146)	0.802(3)	0.158(0.095–0.266)	0.7
浙江Zhejiang	RA	1.232(0.165)	1.978(3)	0.234(0.153–0.338)	1.1
	XS	0.758(0.129)	1.859(4)	7.832(4.218–16.726)	36.1
	YY	1.611(0.262)	1.195(3)	3.253(2.221–4.421)	15.0
	CN	1.509(0.302)	0.154(3)	12.737(8.368–19.391)	58.7
湖北Hubei	XG	1.177(0.199)	0.706(3)	0.359(0.189–0.587)	1.7
	JZ	1.126(0.216)	2.201(3)	0.561(0.279–0.960)	2.6
	JL	0.880(0.133)	0.652(4)	1.742(1.014–3.109)	8.0
安徽Anhui	QS	1.082(0.159)	0.473(3)	0.231(0.142–0.348)	1.1
	LJ	0.943(0.149)	0.735(3)	0.621(0.391–1.036)	2.9
	HZ	0.985(0.199)	0.659(3)	0.267(0.136–0.530)	1.2
江西Jiangxi	SG	1.052(0.154)	0.599(3)	0.398(0.256–0.610)	1.8
江西Jiangxi	NC	0.889(0.119)	0.367(4)	1.535(0.979–2.566)	7.1
江苏Jiangsu	YZ	0.839(0.152)	0.531(3)	0.081(0.040–0.140)	0.4
江苏Jiangsu	HJ	0.953(0.167)	1.454(3)	0.113(0.058–0.193)	0.5
四川Sichuan	LS	1.037(0.161)	0.728(3)	0.245(0.140–0.387)	1.1